This season of agents of shield has certainly been an interesting one. It started out with the introduction of the Ghost Rider and his story arc and it continued with the introduction of LMDs and their story arc.
The end of the season gives hints at great story for season 5. I hope that the reason they are going to space is so that they can become the agents of Sword. I am also hoping that they are going to use this to crossover with the Inhuman TV show.